Title: The Geometry of Molecular Conformations in Cryo-EM
Abstract: Cryo-Electron Microscopy (cryo-EM) is an imaging technology that is revolutionizing structural biology. Cryo-electron microscopes produce many very noisy two-dimensional projection images of individual frozen molecules; unlike related methods, such as computed tomography (CT), the viewing direction of each particle image is unknown. The unknown directions and extreme noise make the determination of the structure of molecules challenging. While other methods for structure determination, such as x-ray crystallography and NMR, measure ensembles of molecules, cryo-electron microscopes produce images of individual particles. Therefore, cryo-EM could potentially be used to study mixtures of conformations of molecules. We will discuss a range of recent methods for analyzing the geometry of molecular conformations using cryo-EM data and some new issues that arise.
Bio: Roy Lederman is an Assistant Professor at the Department of Statistics and Data Science at Yale University. He is also a member of the Quantitative Biology Institute (QBio) and the Wu Tsai Institute (WTI) at Yale. From 2015-2018 he was a postdoc in the Program in Applied and Computational Mathematics at Princeton University, working with Amit Singer. From 2014-2015 he was a Gibbs Assistant Professor in the Applied Mathematics Program at Yale University, where he also got his PhD, working with Vladimir Rokhlin and Raphy Coifman. He has a BSc in physics and a BSc in electrical engineering from Tel-Aviv University.